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Gankyrin-Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

Shuang Li1, Yuky Lam2, Aaron Muth2

  • 1Division of Digestive and Liver Diseases, Irving Cancer Research Center Columbia University Medical Center New York New York USA.

Chronic Diseases and Translational Medicine
|December 4, 2025
PubMed

Insights

Gankyrin (PSMD10), an oncogenic protein overexpressed in gastrointestinal cancers, drives tumor growth and treatment resistance. Targeting gankyrin offers a promising precision oncology strategy for these malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Gankyrin (PSMD10) is a 25 kDa oncogenic protein and a regulatory subunit of the 26S proteasome.
  • It features a characteristic sevenfold ankyrin repeat domain and is overexpressed in various cancers, especially gastrointestinal (GI) cancers.

Purpose of the Study:

  • To review recent advances in understanding gankyrin's role in tumorigenesis.
  • To explore its potential as a diagnostic and prognostic biomarker.
  • To discuss emerging therapeutic strategies targeting gankyrin in GI cancers.

Main Methods:

  • Literature review of recent studies on gankyrin.
  • Analysis of gankyrin's molecular interactions and structural basis.
  • Evaluation of gankyrin's role in key signaling pathways and protein-protein interactions.

Main Results:

  • Gankyrin promotes tumorigenesis by modulating signaling pathways and interacting with tumor suppressors like p53 and Rb.
  • These interactions enhance cell proliferation, metastasis, and treatment resistance.
  • Structural insights reveal mechanisms of gankyrin's molecular interactions.

Conclusions:

  • Gankyrin is a significant contributor to GI cancer development and progression.
  • It holds potential as a valuable biomarker for diagnosis and prognosis.
  • Targeting gankyrin represents a promising therapeutic strategy for precision oncology in GI cancers.
Keywords:
MDM2gankyrininhibitors

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