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Updated: Jan 9, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Copper-Catalyzed Asymmetric Allyl Addition of Imines with Allenylsilanes
Chi Yang1, Menghua Xu2, Aijun Lin2
1Anhui Provincial Joint Key Laboratory for Innovative Drug Research and Industry Integration, School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, People's Republic of China.
Abstract:
A copper-catalyzed allylation of N-tert-butanesulfinyl imines with silylallenes has been developed, affording chiral homoallylic amines bearing multiple stereocenters with excellent stereocontrol. The protocol features mild conditions, broad substrate scope, and robustness on a gram scale. Importantly, the allylsilane motif provides a versatile handle for downstream derivatizations. This strategy offers a practical and stereoselective approach to valuable homoallylic amines, highlighting its potential utility in asymmetric synthesis.
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