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Commonly used C-peptide assays show differing associations with CGM metrics

Catriona Clarke1, Mark W J Strachan2, Fraser W Gibb2,3

  • 1Department of Clinical Biochemistry, NHS Lothian, Edinburgh, UK.

Diabetes, Obesity & Metabolism
|December 4, 2025
PubMed
Abstract

No abstract available in PubMed .

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GPCRs Regulate Adenylyl Cylase Activity01:09

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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
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