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Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

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Published on: December 21, 2014

Pericytes and Lung Vascular Remodeling.

M Elizabeth Moss¹, Marisa C Smit¹, Timothy Klouda¹

¹Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, MA.

Arteriosclerosis, Thrombosis, and Vascular Biology

|December 4, 2025

Summary

Pericytes, crucial for capillary health, are hard to identify. New research highlights their role in pulmonary hypertension and introduces a specific marker, Higd1b, for better identification and potential therapies.

Keywords:

capillaries pericytes pulmonary hypertension vascular remodeling

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Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Area of Science:

Vascular biology and cell biology

Background:

Pericytes are mural cells supporting capillary homeostasis but are difficult to identify due to plasticity and shared markers.
Their role in vascular diseases, particularly pulmonary hypertension, is increasingly recognized but not fully understood.

Purpose of the Study:

To review pericyte morphology, function, and their role in pulmonary hypertension.
To highlight recent advancements in pericyte identification and potential therapeutic strategies.

Main Methods:

Review of historical and recent scientific literature.
Analysis of single-cell RNA sequencing data for novel marker identification.

Main Results:

Pericytes contribute to pulmonary hypertension through phenotypic switching and morphological changes.
A novel, specific pericyte marker, Higd1b, has been identified, improving pericyte identification and revealing subtypes.

Conclusions:

Accurate pericyte identification is crucial for understanding their function in health and disease.
Targeting pericytes offers potential therapeutic avenues for pulmonary hypertension.