Emerging epidemiological trends in primary cutaneous lymphomas: a population-based analysis.

Area of Science:

• Oncology
• Epidemiology
• Dermatology

Background:

• Primary cutaneous lymphomas (CLs), encompassing CTCLs and CBCLs, are rare non-Hodgkin lymphomas with unique epidemiological profiles.
• The trends in CLs incidence over the last decade are not well-documented.

Purpose of the Study:

• To analyze changes in the overall and specific incidence rates of CLs in the US.
• To examine these changes across different sexes, age groups, and ethnic backgrounds.

Main Methods:

• Utilized data from 13,126 CL cases diagnosed between 2010 and 2021 from the Surveillance, Epidemiology, and End Results Program.
• Calculated age-adjusted incidence rates (IRs), five-year relative survival, and annual percentage change.

Main Results:

• Overall CLs IR was 11.9 per 1,000,000 person-years (CTCLs: 8.8; CBCLs: 3.1).
• Incidence of CTCLs and CBCLs declined annually by 2.8% and 4.9% respectively (2014-2021).
• Five-year relative survival was 89.3% for CTCLs and 91.5% for CBCLs.

Conclusions:

• CLs incidence shows varied decline patterns across demographic groups over the past decade.
• Persistent disparities in incidence and survival highlight the need for targeted research and interventions to address inequalities.