Related Experiment Video
Updated: Jan 9, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Practical Post-Functionalizable Iodosulfonylation of Allenes for Integrating Multifunctional Molecules
Shijie Liu1, Dan Cheng1, Chuxiong Peng1
1State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
None:
Herein, we report a post-functionalizable iodosulfonylation of allenes that enables modular synthesis of multifunctional molecules. This transformation proceeds under mild, additive-free, and transition-metal-free conditions in aqueous media, consistent with the concepts of green and sustainable chemistry. Furthermore, a probe integrating an azide handle, a biotin tag, and a BODIPY fluorophore has been synthesized and applied in cellular imaging and target labeling, highlighting the potential of this strategy in interdisciplinary research.
More Related Videos
09:54Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
12:27Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Preparation of Alkynes: Alkylation Reaction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.
Preparation and Reactions of Sulfides
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cycloaddition Reactions: Overview