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Inbreeding depression affecting stayability in Italian Holstein cows.

J C C Panetto1, C Maltecca2, M Ablondi3

  • 1Department of Agriculture, Food, Environment and Forestry, University of Florence, 50144 Florence, Italy; Embrapa Dairy Cattle, 36038-330 Juiz de Fora, Brazil.

Journal of Dairy Science
|December 4, 2025
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Summary
This summary is machine-generated.

Increased inbreeding in Italian Holstein cows negatively impacts their longevity and productivity. Genomic inbreeding measures revealed greater effects on stayability, with recent inbreeding showing a more significant negative impact than ancient inbreeding.

Keywords:
dairyinbreedingpedigreeruns of homozygosity

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Area of Science:

  • Animal Genetics
  • Dairy Cattle Breeding
  • Quantitative Genetics

Background:

  • Advances in genomic selection and assisted reproductive technologies have boosted dairy cattle productivity.
  • Widespread use of elite sires/dams has led to increased inbreeding, risking animal performance.
  • Inbreeding depression affects production, reproduction, and functional longevity in dairy cattle.

Purpose of the Study:

  • To evaluate the effect of inbreeding on stayability in the Italian Holstein population.
  • To compare different methods of estimating inbreeding coefficients (pedigree, genomic, runs of homozygosity).
  • To distinguish the impact of recent versus ancient inbreeding on cow stayability.

Main Methods:

  • Stayability was assessed across 5 parity periods (e.g., STAY12, STAY23).
  • Inbreeding coefficients were estimated using pedigree, genomic relationships, and runs of homozygosity (ROH).
  • Bayesian models estimated inbreeding effects on stayability, including milk yield as a fixed effect.

Main Results:

  • Increased inbreeding consistently decreased stayability in Italian Holstein cows.
  • Genomic inbreeding measures captured larger inbreeding depression effects than pedigree-based methods.
  • Inbreeding from long ROH segments (>2 Mb) reduced stayability, indicating recent inbreeding's negative impact.

Conclusions:

  • Inbreeding significantly reduces cow stayability in the Italian Holstein population.
  • Recent inbreeding poses a greater risk to stayability than ancient inbreeding.
  • Selection indices should incorporate production level and penalize future inbreeding for accurate stayability analysis.