Related Experiment Video
Updated: Jan 9, 2026

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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
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Echocardiographic Evaluation for Safe and Complete Transcatheter Left Atrial Appendage Closure
Mizuki Miura1, Akihiro Isotani2, Masato Fukunaga2
1Department of Medicine, Division of Cardiology, Teikyo University School of Medicine, Tokyo, Japan.
JACC. Case Reports
|December 4, 2025
Summary
The CLOSE-PML sign enhances transcatheter left atrial appendage (LAA) closure by optimizing Amplatzer Amulet device placement. This checklist improves procedural safety and efficacy for durable LAA sealing.
Area of Science:
- Cardiology
- Medical Imaging
- Interventional Procedures
Background:
- Transcatheter left atrial appendage (LAA) closure is a key stroke prevention strategy in atrial fibrillation.
- Standard echocardiography checklists may not fully capture all potential device-structure interactions.
- Optimizing device positioning is crucial for procedural success and long-term efficacy.

