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Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Related Experiment Video

Updated: Jan 9, 2026

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Diabetes and ALDH2 Gene Polymorphism on Post-Ablation Atrial Fibrillation Recurrence.

Junyan Jin1, Ningjing Qian1, Ying Gao1

  • 1Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China; Heart Regeneration and Repair Key Laboratory of Zhejiang Province, Hangzhou, China; Transvascular Implantation Devices Research Institute, Hangzhou, China.

JACC. Asia
|December 4, 2025
PubMed
Summary

Type 2 diabetes mellitus (T2DM) and ALDH2 gene variants significantly increase atrial fibrillation (AF) recurrence post-ablation. Combined risk stratification may identify high-risk patients for targeted prevention strategies.

Keywords:
aldehyde dehydrogenase 2atrial fibrillationgene polymorphismradiofrequency catheter ablationsrecurrencetype 2 diabetes mellitus

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Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Diseases

Background:

  • Type 2 diabetes mellitus (T2DM) and mitochondrial aldehyde dehydrogenase 2 (ALDH2) gene polymorphism are linked to atrial fibrillation (AF) prevalence.
  • Understanding these associations is crucial for managing AF recurrence after treatment.

Purpose of the Study:

  • To assess the combined risk of T2DM and ALDH2 gene polymorphism on AF recurrence after radiofrequency catheter ablation.
  • To identify predictive factors for AF recurrence in patients undergoing ablation.

Main Methods:

  • A prospective multicenter cohort study included 324 patients undergoing their first successful radiofrequency catheter ablation.
  • Patients were stratified by T2DM status and ALDH2 genotype.
  • AF recurrence was analyzed using Kaplan-Meier curves and Cox regression.

Main Results:

  • AF recurrence occurred in 86 patients (26.5%) at a median 12-month follow-up.
  • T2DM patients had a significantly higher recurrence risk (44.3%) compared to non-T2DM patients (19.9%).
  • The combination of T2DM and ALDH2-variant showed the highest cumulative incidence (55.8%) and was the strongest independent predictor of 1-year AF recurrence (aHR: 4.20).

Conclusions:

  • T2DM and ALDH2-variant significantly increase AF recurrence after radiofrequency catheter ablation.
  • The interplay between genetic predisposition and diabetic metabolism underscores the need for combined risk stratification.
  • Targeted preventive strategies are essential for high-risk T2DM patients with AF to reduce recurrence post-ablation.