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Updated: Jan 9, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Preeclampsia, prevalence and associated factors

Martin Chakulya1, Prince Mulambo1,2, Gift C Chama1,2

  • 1Department of Pathology and Microbiology, Mulungushi University, School of Medicine and Health Sciences, Livingstone, Zambia.

Plos One
|December 4, 2025
PubMed

Insights

Maternal age, family history, and prior preeclampsia (PE) history are key factors for developing PE in Zambia. Early screening and enhanced prenatal care are crucial for managing this obstetric complication.

Area of Science:

  • Obstetrics and Gynecology
  • Public Health
  • Epidemiology

Background:

  • Preeclampsia (PE) is a major cause of maternal and fetal mortality in Zambia.
  • High prevalence of pregnancy-related hypertension necessitates identifying PE risk factors.

Purpose of the Study:

  • To identify factors associated with the development of preeclampsia (PE) in Zambia.

Main Methods:

  • Cross-sectional study conducted at Livingstone University Teaching Hospital, Zambia.
  • Included 1018 participants; PE defined by new-onset hypertension and proteinuria.
  • Analyzed demographic, clinical, and hematological parameters using logistic regression.

Main Results:

  • Prevalence of PE was 12.2%.
  • Factors positively associated with PE included increasing maternal age (AOR: 1.07), previous PE history (AOR: 30.8), and family history of PE (AOR: 9.97).
  • Increased gestational age was negatively associated with PE (AOR: 0.89).

Conclusions:

  • Maternal age, family history, and prior obstetric history are significant risk factors for PE.
  • Highlights the need for targeted screening and early intervention strategies.
  • Enhanced prenatal care, including risk assessment and regular monitoring, is vital for PE management.
Abstract

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