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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Association Between Male Circumcision and Cervical Cancer Risk: A Systematic Review and Meta-Analysis of Analytical
Mariya Amin Qurieshi1, Inaamul Haq1, Tazean Zahoor Malik1
1Department of Community Medicine, Government Medical College, Srinagar, India.
JCO Global Oncology
|December 4, 2025
Summary
Male circumcision is linked to reduced odds of cervical cancer in women. This finding suggests a potential protective effect, warranting further investigation into human papillomavirus (HPV) transmission dynamics.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Cervical cancer remains a significant global health concern, particularly for women.
- Understanding risk factors and preventive measures is crucial for public health strategies.
Purpose of the Study:
- To synthesize evidence on the association between male circumcision and cervical cancer risk in females.
- To evaluate the prophylactic potential of male circumcision against cervical lesions.
Main Methods:
- Systematic review of multiple databases including PubMed, Cochrane, and Google Scholar.
- Inclusion of 19 studies assessing male circumcision status and female cervical cancer.
- Risk-of-bias assessment using Newcastle-Ottawa scales and estimation of summary odds ratios.
Main Results:
- Male circumcision was associated with significantly decreased odds of cervical cancer (OR, 0.65).
- Reduced odds were observed for invasive cervical cancer (OR, 0.71), cervical dysplasia (OR, 0.65), and carcinoma in situ (OR, 0.67).
- The analysis included 19 studies with a generally low risk of bias.
Conclusions:
- Male circumcision demonstrates a potential prophylactic role against various cervical lesions.
- Further research on male circumcision's impact on human papillomavirus (HPV) infection is recommended.
- Understanding HPV transmission is key to elucidating cervical cancer pathogenesis.
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