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Challenges and Opportunities for Cancer Clinical Trials Development in Latin America.

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Latin America (LATAM) has a growing cancer burden but low oncology trial participation. Enhancing academic investment and addressing structural challenges can boost LATAM

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Area of Science:

  • Oncology
  • Clinical Trials
  • Health Equity

Background:

  • Latin America (LATAM) represents over 8% of the global population and faces a significant and increasing cancer burden.
  • Despite this, the region contributes less than 2% to global oncology clinical trial activity and scientific output.
  • LATAM's research ecosystem is challenged by a lack of sustained academic investment, hindering its ability to complement industry-led trials.

Purpose of the Study:

  • To analyze the current landscape of cancer clinical trials in LATAM.
  • To identify structural challenges and emerging opportunities within the region's research environment.
  • To propose actionable priorities for enhancing LATAM's role in global oncology research.

Main Methods:

  • Review of recent data and institutional experiences in LATAM.
  • Analysis of the region's reliance on industry-led studies and academic ecosystems.
  • Assessment of factors constraining investigator-led innovation, including regulatory, infrastructural, and resource limitations.

Main Results:

  • LATAM's oncology research is characterized by a dual reliance on industry-sponsored trials and fragile academic initiatives.
  • Regulatory disparities, inadequate infrastructure, and limited access to biobanks and registries impede innovation.
  • Factors such as high patient adherence, cost-efficiency, and developing cooperative networks present opportunities for growth.

Conclusions:

  • LATAM faces significant hurdles in cancer clinical research due to structural and financial constraints.
  • The region possesses unique advantages that can be leveraged to increase its contribution to global oncology research.
  • Strategic investments in funding, regulatory harmonization, workforce development, and research equity are crucial for transforming LATAM into a key contributor of oncology evidence.