Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

334
Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
334
Models of Health Promotion and Illness Prevention I01:25

Models of Health Promotion and Illness Prevention I

2.6K
A model is a theoretical way to understand a concept or an idea. Models can overcome barriers to health regardless of diverse economic and cultural backgrounds. In addition, models make the task easier by providing different ways to approach complex issues. There are two major health promotion models: the health belief model and the health promotion model.
The health belief model (HBM) attempts to predict health-related behavior in specific belief patterns. According to the HBM, a person's...
2.6K
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

226
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
226
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

309
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
309
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

1.8K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
1.8K
Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

527
Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
527

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Do you guys tell anybody?": Exploring allocation and implementation of opioid settlement funds and reduced access to health vending machines for people who use drugs.

Journal of studies on alcohol and drugs·2026
Same author

Profiles of stress and their associations with substance use among adults of color.

Drug and alcohol dependence·2026
Same author

Passport to Wellness Intervention: Selecting and Training Peer Mentors and Their Reflections on Supporting to Black Sexual Minority Men's Social and Health Needs.

Journal of homosexuality·2026
Same author

Understanding the Impact of Structural Racism and Violence Across the Lifespan on Overdose Vulnerability Among Black San Franciscans Experiencing Homelessness.

Journal of psychoactive drugs·2026
Same author

Healthcare First: Delivering Immediate, Non-Contingent, and Coordinated Services Through the Street Medicine Model.

Research square·2026
Same author

Hidden nicotine: Cotinine levels among young adult Black men who smoke cannabis blunts.

Drug and alcohol dependence·2026

Related Experiment Video

Updated: Jan 9, 2026

Novel Apparatus and Method for Drug Reinforcement
07:32

Novel Apparatus and Method for Drug Reinforcement

Published on: August 20, 2010

19.8K

Breaking barriers: evaluating access models for harm reduction vending machines.

Ashleigh Herrera1, Bradley Conner2, Presleigh Beshirs1

  • 1California State University Bakersfield, Department of Social Work, 9001 Stockdale Highway, Bakersfield, CA 93311, United States.

The International Journal on Drug Policy
|December 4, 2025
PubMed
Summary

Removing barriers like registration and limits from harm reduction vending machines (HRVMs) significantly increased the use of essential supplies like naloxone kits. This improves access to vital resources for marginalized communities.

Keywords:
Access modelsHarm reduction suppliesHarm reduction vending machineNaloxoneNaloxone vending machinePublic health vending machine

More Related Videos

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.5K
A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.8K

Related Experiment Videos

Last Updated: Jan 9, 2026

Novel Apparatus and Method for Drug Reinforcement
07:32

Novel Apparatus and Method for Drug Reinforcement

Published on: August 20, 2010

19.8K
Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

8.5K
A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.8K

Area of Science:

  • Public Health
  • Epidemiology
  • Health Equity

Background:

  • The opioid epidemic causes significant mortality, especially in marginalized communities.
  • Structural barriers limit equitable access to critical interventions like naloxone.
  • Harm reduction vending machines (HRVMs) present a low-barrier solution for distributing naloxone and other supplies.

Purpose of the Study:

  • To examine the impact of different HRVM access models on product utilization.
  • To assess changes in utilization after removing registration and product limits from an outdoor HRVM.

Main Methods:

  • Interrupted time series analysis of data from June to October 2023.
  • Focus on an outdoor HRVM (Project HOPE) in Bakersfield, California.
  • Comparison of product utilization before and after removing access restrictions.

Main Results:

  • A significant increase in product utilization was observed after unrestricted access was implemented.
  • Demand surged for naloxone kits, safer injection kits, wound care kits, and basic needs supplies.
  • Removing registration requirements and product limits demonstrably improved supply utilization.

Conclusions:

  • Unrestricted access models for HRVMs can substantially boost the uptake of harm reduction supplies.
  • This approach has the potential to reduce opioid-related fatalities and advance health equity.
  • Further research is warranted to explore the long-term effects on overdose prevention and health outcomes.