Study on antibacterial lubricating coatings for oral implants based on electrostatic self-assembly and Schiff base...

Bacterial infection at the surface of oral implants is one of the primary reasons for surgical failure. To counter the risk of biofilm infection on oral implants and prevent the emergence of drug-resistant bacteria, an increasing number of researchers are focusing on the study of surface coatings for oral implants. Therefore, an antibacterial hydrophilic coating was developed in this study. This coating combines a biomimetic adhesive (dopamine-modified oxidized hyaluronic acid) with a long-acting drug-loaded carrier (aminated mesoporous silica particles) on a polyurethane material through electrostatic self-assembly and a Schiff base reaction. The results showed that the drug-loaded mesoporous silica nanoparticles prepared by the solvent template method had a diameter of approximately 200 nm and a pore size of about 3 nm. The drug could be continuously released in vitro for more than 9 days. Dopamine-modified hyaluronic acid can firmly adhere the drug-loaded mesoporous silica nanoparticles to the material surface, forming a uniform and stable coating. Additionally, the composite coating exhibited effective antibacterial properties against S. aureus and E. coli. The CCK-8 and fluorescence staining results showed that the coating had excellent biocompatibility.