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Updated: Jan 9, 2026

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Horizontal Hippocampal Slices of the Mouse Brain
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Parallel supramammillary-hippocampal routes: Organization, dysregulation, and restoration
1Department of Psychiatry of Sir Run Run Shaw Hospital, Department of Neurology of Second Affiliated Hospital, and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100, China.
Neuron
|December 4, 2025
Abstract
None:
In this issue of Neuron, Luo et al.1 report two supramammillary neuronal populations with segregated projections to the dorsal and ventral dentate gyrus that selectively modulate cognitive and emotional processes, respectively. Targeted activation of each pathway alleviates domain-specific behavioral deficits in an Alzheimer's disease mouse model.

