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Related Concept Videos

Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

161
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
161
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

225
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
225

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Related Experiment Video

Updated: Jan 9, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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CD36 and Its Role in Obesity.

Nahuel Garcia1, Maiken Mellergaard2,3, Carlos Salomon4

  • 1GECORP, Buenos Aires, Argentina.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

CD36 plays a key role in fat storage and ectopic fat accumulation, contributing to obesity complications. Understanding CD36 pathways may lead to new obesity treatments targeting lipid metabolism.

Keywords:
CD36ectopic fatobesity

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Area of Science:

  • Metabolic research
  • Obesity research
  • Lipid metabolism

Background:

  • Obesity results from complex genetic and environmental interactions.
  • CD36 is central to lipid metabolism and ectopic fat deposition.
  • Ectopic fat accumulation in non-adipose tissues drives obesity-related diseases like MASLD and cardiovascular issues.

Purpose of the Study:

  • To review the multifaceted role of CD36 in lipid metabolism and ectopic fat accumulation.
  • To re-examine the adipose tissue expandability hypothesis with CD36 as a key regulator.
  • To explore CD36's genetic links to obesity predisposition and management.

Main Methods:

  • Literature review focusing on CD36 function in lipid handling.
  • Analysis of CD36's role in adipose and non-adipose tissue lipid storage.
  • Examination of genetic evidence linking CD36 to obesity.

Main Results:

  • CD36 facilitates fatty acid uptake and regulates lipid storage location.
  • CD36 influences adipose tissue expandability, potentially driving lipid spillover to ectopic sites.
  • CD36 is implicated in inter-tissue communication via extracellular vesicles, amplifying ectopic fat deposition.
  • Genetic variations in CD36 correlate with obesity susceptibility and management.

Conclusions:

  • CD36 is a critical regulator of the metabolic tipping point between healthy and pathogenic fat deposition.
  • Targeting CD36 pathways offers potential for personalized therapeutic strategies against obesity and its complications.
  • Further research into CD36 and extracellular vesicle interactions may reveal novel therapeutic targets.