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Knee Joint

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...

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Related Experiment Video

Updated: May 2, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses.

Miguel Otero¹, Irene Lorenzo Gomez², Takuya Sakamoto²

¹Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.

Laboratory Investigation; a Journal of Technical Methods and Pathology

|December 4, 2025

Summary

This summary is machine-generated.

Understanding knee osteoarthritis requires standardized tissue analysis. This review highlights the need for consistent scoring systems in knee joint tissues to improve research reproducibility and our comprehension of aging and osteoarthritis.

Keywords:

histology scoring macroscopic scoring omics osteoarthritis standardization tissue processing

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Last Updated: May 2, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

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Published on: September 2, 2025

Area of Science:

Orthopedics
Biomedical Engineering
Molecular Biology

Background:

Knee joint tissues undergo changes during aging and osteoarthritis.
Current understanding of knee organ homeostasis and tissue crosstalk is limited.
Novel molecular profiling imaging technologies offer new research avenues.

Purpose of the Study:

To review current methods for characterizing knee joint tissues.
To discuss limitations in existing macroscopic and histological scoring systems.
To propose standardized approaches for tissue evaluation in osteoarthritis research.

Main Methods:

Review of current literature on knee tissue analysis.
Discussion of limitations in macroscopic and histological scoring.
Proposal of consistent features for cross-tissue evaluation.

Main Results:

Existing scoring systems for knee joint tissues lack universal acceptance.
Variability in feature selection and quantification hinders comparability.
Standardization is crucial for minimizing experimental variability.

Conclusions:

A universally accepted scoring system for knee joint tissues is needed.
Standardized evaluation of macroscopic and histological features is essential.
Proposed approaches aim to improve reproducibility in osteoarthritis research.