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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Related Experiment Video

Updated: Jan 9, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Practices in platelet production: A Nordic perspective (2018-2022).

Aseel Alshamari1, Tynngård Nahreen2,3, Jarkko Ihalainen4

  • 1Department of Clinical Immunology and Transfusion Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Vox Sanguinis
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

Nordic platelet concentrate production varies. Implementing pathogen reduction or bacterial culture screening with 7-day storage could enhance regional blood supply resilience and safety.

Keywords:
Nordic regionbacterial culture screeningpathogen reductionplatelet concentrateplatelets

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Public Health

Background:

  • The Nordic region, with over 27.5 million people, has diverse blood service management across Denmark, Finland, Iceland, Norway, and Sweden.
  • Understanding current platelet concentrate (PC) production methods and capacity is crucial for regional efficiency and preparedness.

Purpose of the Study:

  • To survey and analyze PC production methods, safety measures, and capacity in the Nordic region between 2018 and 2022.
  • To identify variations in collection procedures, bacterial screening, and storage practices.

Main Methods:

  • A retrospective online survey was conducted among all Nordic blood centers producing platelets.
  • Data collected covered collection methods (apheresis vs. whole blood-derived), bacterial culture screening (BCS), pathogen reduction (PR), shelf-life, and quality control.

Main Results:

  • 43 blood centers participated (83% response rate), covering national data for Finland, Iceland, and Sweden.
  • Between 2018-2022, 632,596 PCs were produced; most were whole blood-derived pools (77%).
  • Pathogen reduction was used in 17 centers, BCS in 23. Shelf-life extended to 7 days with PR or BCS, compared to 5 days without.

Conclusions:

  • Significant variation exists in Nordic platelet production and safety measures against bacterial contamination.
  • Harmonizing practices, including the adoption of PR or BCS for extended 7-day shelf-life, could bolster regional platelet supply resilience.