Practices in platelet production: A Nordic perspective (2018-2022)

Area of Science:

• Transfusion Medicine
• Hematology
• Public Health

Background:

• The Nordic region, with over 27.5 million people, has diverse blood service management across Denmark, Finland, Iceland, Norway, and Sweden.
• Understanding current platelet concentrate (PC) production methods and capacity is crucial for regional efficiency and preparedness.

Purpose of the Study:

• To survey and analyze PC production methods, safety measures, and capacity in the Nordic region between 2018 and 2022.
• To identify variations in collection procedures, bacterial screening, and storage practices.

Main Methods:

• A retrospective online survey was conducted among all Nordic blood centers producing platelets.
• Data collected covered collection methods (apheresis vs. whole blood-derived), bacterial culture screening (BCS), pathogen reduction (PR), shelf-life, and quality control.

Main Results:

• 43 blood centers participated (83% response rate), covering national data for Finland, Iceland, and Sweden.
• Between 2018-2022, 632,596 PCs were produced; most were whole blood-derived pools (77%).
• Pathogen reduction was used in 17 centers, BCS in 23. Shelf-life extended to 7 days with PR or BCS, compared to 5 days without.

Conclusions:

• Significant variation exists in Nordic platelet production and safety measures against bacterial contamination.
• Harmonizing practices, including the adoption of PR or BCS for extended 7-day shelf-life, could bolster regional platelet supply resilience.