Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Isotopes and Radioisotopes01:28

Isotopes and Radioisotopes

In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing more...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Cures Act-Forged Pathway to Patient-Tailored Radiopharmaceutical Therapy and Call for Regulatory Transparency.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

MEK-dependent bioenergetic demand drives terminal CD8<sup>+</sup> T cell exhaustion.

bioRxiv : the preprint server for biology·2025
Same author

Determination of the Intralesional Distribution of Theranostic <sup>124</sup>I-Omburtamab Convection-Enhanced Delivery in Treatment of Diffuse Intrinsic Pontine Glioma.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Consensus Nomenclature for Radionuclide Therapy: Initial Recommendations from Nuclear Medicine Global Initiative.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Phase 1 dose-escalation trial using convection-enhanced delivery of radio-immunotheranostic 124I-Omburtamab for diffuse intrinsic pontine glioma.

Neuro-oncology·2025
Same author

Dosimetry for Radiopharmaceutical Therapy: Practical Implementation, From the <i>AJR</i> Special Series on Quantitative Imaging.

AJR. American journal of roentgenology·2025

Related Experiment Video

Updated: May 12, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.4K

Radiation Dosimetry in Theranostics: A Review.

Pat Zanzonico1

  • 1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York zanzonip@mskcc.org.

Journal of Nuclear Medicine Technology
|December 4, 2025
PubMed
Summary
This summary is machine-generated.

Theranostics combines therapy and diagnostics for personalized radiopharmaceutical therapy (RPT). Patient-specific dosimetry in RPT can improve treatment efficacy and reduce toxicity, though more trials are needed.

Keywords:
dosimetryradiation therapy planningradiobiologyradionuclide therapyradiopharmaceutical therapy

More Related Videos

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.5K
Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.6K

Related Experiment Videos

Last Updated: May 12, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.4K
Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.5K
Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.6K

Area of Science:

  • Nuclear Medicine
  • Radiopharmacology
  • Medical Physics

Background:

  • Theranostics integrates therapy and diagnostics, leveraging radiopharmaceuticals for imaging and treatment.
  • Radiopharmaceutical therapy (RPT) allows in vivo imaging to measure drug activity in target lesions and organs.
  • Personalized RPT, guided by dosimetry, offers potential for reduced toxicity and enhanced efficacy compared to fixed-activity approaches.

Purpose of the Study:

  • To highlight the adaptability and advantages of theranostics in radiopharmaceutical therapy.
  • To discuss the role of patient-specific dosimetry in optimizing RPT outcomes.
  • To address the challenges and future directions for dosimetry-based RPT.

Main Methods:

  • Review of theranostics principles and their application in RPT.
  • Discussion of dosimetry-based personalized RPT versus fixed-activity RPT.
  • Analysis of current dose-response data and requirements for future clinical trials.

Main Results:

  • Theranostics enables noninvasive in vivo measurement of radiopharmaceutical activity.
  • Personalized RPT based on dosimetry shows promise for improved efficacy and lower toxicity.
  • Obstacles to dosimetry-based RPT are diminishing, supported by emerging dose-response data.

Conclusions:

  • Patient-specific dosimetry holds significant potential to optimize radiopharmaceutical therapy.
  • Further multicenter trials with standardized protocols are crucial to establish the definitive value of dosimetry in RPT.
  • Standardization of calibration, acquisition, and reconstruction methods is essential for future RPT trials.