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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
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Radiation Dosimetry in Theranostics: A Review.
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York zanzonip@mskcc.org.
Journal of Nuclear Medicine Technology
|December 4, 2025
Summary
Theranostics combines therapy and diagnostics for personalized radiopharmaceutical therapy (RPT). Patient-specific dosimetry in RPT can improve treatment efficacy and reduce toxicity, though more trials are needed.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Medical Physics
Background:
- Theranostics integrates therapy and diagnostics, leveraging radiopharmaceuticals for imaging and treatment.
- Radiopharmaceutical therapy (RPT) allows in vivo imaging to measure drug activity in target lesions and organs.
- Personalized RPT, guided by dosimetry, offers potential for reduced toxicity and enhanced efficacy compared to fixed-activity approaches.
Purpose of the Study:
- To highlight the adaptability and advantages of theranostics in radiopharmaceutical therapy.
- To discuss the role of patient-specific dosimetry in optimizing RPT outcomes.
- To address the challenges and future directions for dosimetry-based RPT.
Main Methods:
- Review of theranostics principles and their application in RPT.
- Discussion of dosimetry-based personalized RPT versus fixed-activity RPT.
- Analysis of current dose-response data and requirements for future clinical trials.
Main Results:
- Theranostics enables noninvasive in vivo measurement of radiopharmaceutical activity.
- Personalized RPT based on dosimetry shows promise for improved efficacy and lower toxicity.
- Obstacles to dosimetry-based RPT are diminishing, supported by emerging dose-response data.
Conclusions:
- Patient-specific dosimetry holds significant potential to optimize radiopharmaceutical therapy.
- Further multicenter trials with standardized protocols are crucial to establish the definitive value of dosimetry in RPT.
- Standardization of calibration, acquisition, and reconstruction methods is essential for future RPT trials.
Keywords:
dosimetryradiation therapy planningradiobiologyradionuclide therapyradiopharmaceutical therapyMore Related Videos
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