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Related Experiment Video

Updated: Jan 9, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Molecular glues evolve from serendipity to rational design.

Princy Shrivastav¹, Rohit Singh², Andrew J Wiemer³

¹School of Health Sciences & Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra 411038, India.

Trends in Pharmacological Sciences

|December 4, 2025

Summary

Molecular glues (MGs) are compounds that modulate protein interactions. Rational design approaches and emerging technologies are advancing MGs from natural products to synthetic therapeutics in clinical trials.

Keywords:

14-3-3 E3 ligase PROTAC butyrophilin immunomodulatory drugs ubiquitin-proteasome

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Last Updated: Jan 9, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Published on: May 8, 2015

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Area of Science:

Medicinal Chemistry
Chemical Biology
Drug Discovery

Background:

Molecular glues (MGs) are a class of small molecules that modulate protein interactions.
Classical MGs were discovered serendipitously, presenting a challenge for rational design.
Understanding structure-activity relationships (SAR) is crucial for developing novel MGs.

Purpose of the Study:

To highlight the evolution of molecular glues from natural products to synthetic compounds.
To discuss the integration of emerging technologies for the rational design of MGs.
To showcase the increasing target diversity and clinical potential of MGs.

Main Methods:

Review of historical discoveries and serendipitous findings of MGs.
Analysis of recent advances in understanding MG structure-activity relationships (SAR).
Exploration of emerging structure-based design technologies.

Main Results:

Significant progress has been made in the rational design of novel molecular glues.
Structure-based design technologies have expanded the range of druggable targets for MGs.
Multiple MG candidates are currently undergoing clinical trials, indicating therapeutic promise.

Conclusions:

Molecular glues represent a rapidly evolving therapeutic modality.
Integration of advanced technologies is key to unlocking the full potential of rational MG design.
Emerging synthetic MGs hold significant promise for future therapeutic applications.