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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
Published on: January 12, 2024
Evolution of proteolysis-targeting chimeras (PROTAC) technology to overcome challenges of antimicrobial resistance
Dhanashree N Sarwan1, Pramod B Khedekar1, Ritesh P Bhole2
1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India.
Abstract:
Targeted protein degradation (TPD) is an innovative therapeutic approach that bypasses traditional drug inhibition methods. Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that harness degradation machinery to remove target proteins. This review examines the evolution of PROTACs and their application in targeting microorganisms that develop drug resistance, covering their development, advancements in linker design, E3 ligase selection, and delivery methods, including nanoparticles and exosomes.
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