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Related Experiment Video

Updated: Jan 9, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

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Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation-A Case Study.

Mengxuan Tang1, Amerta Bai1, Felipe Rodridgues Marques Ferreira1

  • 1Department of Neurology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.

Annals of Clinical and Translational Neurology
|December 5, 2025
PubMed
Summary

New-onset refractory status epilepticus (NORSE) is a severe condition. Targeting thalamic pulvinar nuclei with sensing-enabled deep brain stimulation (DBS) improved seizure burden in a refractory case.

Area of Science:

  • Neurology
  • Neurosurgery
  • Epileptology

Background:

  • New-onset refractory status epilepticus (NORSE) presents a critical challenge with high mortality and morbidity.
Keywords:
deep brain stimulationepilepsystatus epilepticusthalamic neuromodulatory targets

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  • Established treatments including anti-seizure medications, anesthetics, and immunomodulation often prove insufficient.
  • Deep brain stimulation (DBS) targeting specific thalamic nuclei shows potential for refractory cases.