Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating Associations Between Cumulative Use of Chronic Liver Injury-Inducing Antiretroviral Therapy and Hepatocellular Carcinoma, By Chronic Liver Disease Status.

Journal of acquired immune deficiency syndromes (1999)·2026

Same author

Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators.

British journal of clinical pharmacology·2026

Same author

Ambient Temperature and Psoriatic Arthritis Odds Among Patients With Psoriasis: A Cross-sectional Analysis.

Journal of psoriasis and psoriatic arthritis·2026

Same author

Clinician Perceptions of Therapeutic Inertia in Type 2 Diabetes Mellitus: A Qualitative Study.

Journal of the American College of Clinical Pharmacy : JACCP·2026

Same author

Strategies to Enhance Satisfaction and Success in an Academic Career in Pharmacoepidemiology.

Pharmacoepidemiology and drug safety·2026

Same author

Brain penetrant calcium channel blockers do not reduce alcohol consumption: Converging results from two large independent cohort studies using electronic health records.

medRxiv : the preprint server for health sciences·2026

Same journal

Effectiveness of Metformin in Preventing Colorectal Cancer Among Japanese Patients With Type 2 Diabetes: A Target Trial Emulation.

Pharmacoepidemiology and drug safety·2026

Same journal

Trends in Pharmacist-Prescribed Dispensing Records of HIV Pre-Exposure (2020-2025) and Post-Exposure Prophylaxis (2020-2024) in Brazil: A Time Series Analysis.

Pharmacoepidemiology and drug safety·2026

Same journal

French Consumption of Methylphenidate in Primary Care From 2016 to 2023, Impact of Prescribing Policy Changes-A Time-Series Analysis.

Pharmacoepidemiology and drug safety·2026

Same journal

Uptake and Use of Biologic Therapies in Paediatric Immune-Mediated Inflammatory Diseases: An Australian Population-Based Study.

Pharmacoepidemiology and drug safety·2026

Same journal

Comparative Effectiveness of Oral Fluoropyrimidines Versus FOLFOX as Adjuvant Therapy for Stage III Colon Cancer: A Retrospective Cohort Study Using Overlap-Weighted Restricted Mean Survival Time Analysis.

Pharmacoepidemiology and drug safety·2026

Same journal

Association Between EGFR-TKI-Associated Skin Rash and Recorded Mortality in Non-Small Cell Lung Cancer: A Real-World Analysis Accounting for Immortal Time Bias.

Pharmacoepidemiology and drug safety·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With

Vincent Lo Re^1,2, Craig W Newcomb², Dean M Carbonari²

¹Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Pharmacoepidemiology and Drug Safety

|December 5, 2025

Summary

This summary is machine-generated.

This study used tree-based scan statistics on real-world data to identify drugs linked to severe acute liver injury (ALI). Findings highlight potential hepatotoxic medications for further investigation in pharmacoepidemiology research.

Keywords:

acute liver injury drug‐induced liver injury hepatotoxicity high‐throughput screening tree‐based scan statistics

More Related Videos

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Related Experiment Videos

Last Updated: Jan 9, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

Area of Science:

Pharmacovigilance
Real-world data analysis
Hepatotoxicity detection

Background:

Traditional identification of drug-induced liver injury relies on case reports.
High-throughput screening of real-world data offers a scalable approach to detect hepatotoxicity signals.

Purpose of the Study:

To apply tree-based scan statistics to real-world data for identifying drugs associated with hospitalization for severe acute liver injury (ALI).
To conduct separate analyses for patients without liver/biliary disease and those with chronic liver disease (CLD).

Main Methods:

A self-controlled case-crossover design was implemented using Veterans Health Administration data (2000-2023).
Conditional Bernoulli tree-based scan statistics were used to identify potential drug-ALI associations (p < 0.3).
Analyses were performed on patients hospitalized for laboratory-confirmed severe ALI.

Main Results:

Among patients without liver/biliary disease, associated drugs included acid-suppressives (ranitidine, omeprazole) and antiemetics (ondansetron).
In patients with chronic liver disease (CLD), associated drugs included diuretics (spironolactone, furosemide), antiemetics, and analgesics (morphine, oxycodone, fentanyl).
Specific antibiotics and chemotherapy agents were also identified in both patient groups.

Conclusions:

High-throughput screening with tree-based scan statistics effectively detected potentially hepatotoxic drugs.
These findings warrant further investigation in pharmacoepidemiology studies to confirm drug safety signals.