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Narrative Review: Gut Microbiota and Its Impact on α-syn Function in Parkinson's Disease

I Daniel Salinas-Velarde1, Juan Manuel Donaciano-Domínguez1, Rigoberto Oros-Pantoja1

  • 1Facultad de Medicina, Universidad Autónoma del Estado de México, Estado de México, México.

Microbiologyopen
|December 5, 2025
PubMed

Insights

Alterations in gut microbiota (GM) are linked to Parkinson's disease (PD) progression and symptoms. Modulating GM offers potential therapeutic strategies for PD by targeting the gut-brain axis.

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Gut microbiota (GM) alterations are implicated in neurological disorders like Parkinson's disease (PD).
  • Specific bacterial taxa and their metabolites correlate with PD motor symptoms and intestinal dysfunction.
  • Bacterial influence on alpha-synuclein (α-syn) aggregation and neurodegeneration is increasingly recognized.

Purpose of the Study:

  • To review the current understanding of the gut-brain axis in PD.
  • To explore the relationship between GM and α-syn function in PD models and patients.
  • To examine microbiome-modulating therapies for PD.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of studies on gut-brain axis in PD.
  • Examination of therapeutic strategies targeting GM.

Main Results:

  • Evidence links specific gut bacteria and metabolites to PD severity.
  • GM influences α-syn aggregation and neurodegeneration.
  • Therapeutic interventions targeting GM show promise for PD.

Conclusions:

  • GM plays a significant role in PD pathogenesis via the gut-brain axis.
  • Mechanisms include inflammation, immune modulation, and metabolite production.
  • Targeting the microbiome presents novel therapeutic avenues for PD.
Keywords:
Parkinson's Diseasedysbiosisgut microbiotainflammatory processesnutrition

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