Lhermitte's Phenomenon as the Presenting Symptom of Vitamin B12 Deficiency With Complete Reversibility of Neurological and Radiological Abnormalities
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View abstract on PubMed
Summary
This summary is machine-generated.Vitamin B12 deficiency can cause neurological issues like myelopathy, even with normal vitamin levels. Early treatment of vitamin B12 deficiency reversed both symptoms and MRI findings in a patient with neurological dysfunction.
Area Of Science
- Neurology
- Hematology
- Nutritional Science
Background
- Vitamin B12 deficiency is a known cause of reversible neurological dysfunction, including myelopathy.
- Neurological symptoms can manifest without typical hematologic abnormalities or significantly low vitamin B12 levels.
Purpose Of The Study
- To present a case of Lhermitte's sign and paresthesia due to vitamin B12 deficiency.
- To highlight the diagnostic challenges and importance of early recognition and treatment in such cases.
Main Methods
- Case report of a 37-year-old male presenting with neurological symptoms.
- Laboratory evaluation including serum B12 levels and intrinsic factor antibodies.
- Cervical spine MRI to assess spinal cord abnormalities.
Main Results
- Patient exhibited low-normal serum B12 with elevated intrinsic factor antibodies.
- Cervical MRI showed hyperintensity in the posterior spinal cord columns (C2-C5).
- Neurological symptoms and MRI findings resolved completely after vitamin B12 supplementation.
Conclusions
- Neurological manifestations of vitamin B12 deficiency can occur despite normal B12 levels and absence of anemia.
- Early diagnosis and treatment are crucial for reversing clinical and radiological evidence of vitamin B12-related myelopathy.
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