Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

609
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
609
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

563
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
563
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

267
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
267
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

3.8K
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
3.8K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

377
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
377
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

297
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
297

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary coexistence of immunoglobulin light chain amyloidosis and light chain deposition disease: A case report.

Respiratory medicine case reports·2026
Same author

Recurrent Multilevel Calcified Lumbar Disk Herniation Successfully Managed by Lumbar Spinal Fusion: A Rare Case Report.

Journal of orthopaedic case reports·2026
Same author

Role of Dlk1-Notch signaling in impaired neurogenesis and cognitive decline in chronic cerebral hypoperfusion.

Biochemistry and biophysics reports·2026
Same author

Incidental extra-spinal lesions on preoperative lumbar spine CT: frequency, clinical significance, and management implications.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same author

EBV-associated histological transformation of marginal zone lymphomas: two case reports and a literature review.

Virchows Archiv : an international journal of pathology·2026
Same author

A C-Propeptide Variant in COL1A1 Potentially Perturbing Disulfide Bonding in Osteogenesis Imperfecta Type III.

Congenital anomalies·2026

Related Experiment Video

Updated: Jan 9, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

509

VEXAS Syndrome Presenting With Pleuritis.

Makoto Ito1,2, Yasushi Murakami3, Michita Suzuki4

  • 1Department of Hematology Tokoname City Hospital Tokoname Japan.

Clinical Case Reports
|December 5, 2025
PubMed
Summary

VEXAS syndrome, characterized by systemic inflammation and cytopenias in elderly men, can be caused by somatic UBA1 mutations. Pulmonary issues like pleuritis are key indicators, prompting early corticosteroid treatment.

Keywords:
UBA1 mutationVEXAS syndromemyelodysplastic syndromepleuritis

More Related Videos

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
05:50

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

14.5K
Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
03:22

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

Published on: November 10, 2023

1.4K

Related Experiment Videos

Last Updated: Jan 9, 2026

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

509
International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
05:50

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

14.5K
Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
03:22

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

Published on: November 10, 2023

1.4K

Area of Science:

  • Hematology
  • Genetics
  • Pulmonology

Background:

  • VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is an emerging condition.
  • It affects elderly males, presenting with systemic inflammation, cytopenias, and bone marrow vacuolization.
  • Pulmonary involvement is increasingly recognized.

Purpose of the Study:

  • To highlight the association between VEXAS syndrome and somatic UBA1 mutations.
  • To emphasize pulmonary manifestations, such as pleuritis, as potential early signs.
  • To underscore the importance of early diagnosis for timely treatment.

Main Methods:

  • Case identification of elderly men with characteristic symptoms.
  • Genetic analysis to detect somatic UBA1 mutations.
  • Clinical review focusing on pulmonary findings.

Main Results:

  • Somatic UBA1 mutations were identified in affected individuals.
  • Pleuritis was a significant pulmonary manifestation, even without classic chondritis.
  • Early recognition of these symptoms correlated with prompt corticosteroid initiation.

Conclusions:

  • VEXAS syndrome should be considered in elderly men with unexplained inflammation, cytopenias, and bone marrow vacuolization.
  • Pulmonary involvement, particularly pleuritis, is a crucial diagnostic clue.
  • Timely diagnosis and treatment with corticosteroids can improve outcomes.