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Updated: Jan 9, 2026
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary
Xiaodie Yang1,2, Hong Yang3, Dongyi Shen4
1Department of Traditional Chinese Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Background And Purpose:
We aimed to explore the mechanisms and pathways of exercise-based interventions in the treatment of polycystic ovarian syndrome (PCOS).
Methods:
In this literature review, studies related to exercise therapy for PCOS that were published in the past 20 years were searched, potentially effective active ingredients were screened, and gene prediction of active ingredients and diseases was conducted using the compound and GeneCards databases, respectively, to identify potential targets of exercised-related bioactive molecules in PCOS. Finally, hub genes and signaling pathways were predicted using bioinformatic methods.
Results:
The review identified eight potential effective components were screened out, including irisin, 5α-reductase, kisspeptin, cocaine-and amphetamine-regulated transcript, nerve growth factor, nerve peptide Y, insulin-like growth factor-1, and interleukin-6. A total of 192 target genes for exercise-related components and PCOS were identified, including the hub genes TNF, IL6, IL1B, JUN, CCND1, and PSMA7.
Conclusion:
The hub genes identified in this review indicate that exercise therapy in PCOS may affect the protease system, renin-angiotensin system, inflammatory signal transduction, neuroactive ligand-receptor interaction, and other pathways through the G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, endocrine process, and other biological processes and regulate apoptosis, cell cycle, and intercellular communication.
Insights
Exercise interventions for polycystic ovarian syndrome (PCOS) may influence key biological pathways. This review identified bioactive molecules and hub genes, offering insights into PCOS treatment mechanisms.
Area of Science:
- Endocrinology
- Genetics
- Exercise Physiology
Background:
- Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder.
- Understanding the molecular mechanisms of exercise interventions in PCOS is crucial for effective treatment.
Purpose of the Study:
- To explore the mechanisms and pathways of exercise-based interventions for PCOS.
- To identify potential therapeutic targets for exercise in PCOS management.
Main Methods:
- Literature review of exercise therapy for PCOS (last 20 years).
- Screening of potentially effective bioactive components.
- Gene prediction and bioinformatic analysis to identify hub genes and pathways.
Main Results:
- Eight potential effective components identified, including irisin and insulin-like growth factor-1.
- 192 target genes identified, with key hub genes including TNF, IL6, and IL1B.
- Bioinformatic analysis predicted involvement in inflammatory, endocrine, and signaling pathways.
Conclusions:
- Exercise therapy for PCOS impacts multiple biological systems.
- Potential pathways include renin-angiotensin, inflammatory signaling, and neuroactive ligand-receptor interactions.
- Exercise may regulate apoptosis, cell cycle, and intercellular communication in PCOS.
