Related Experiment Video

Updated: Jan 9, 2026

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

9.1K

G protein-coupled receptors in prostate cancer: research progress and therapeutic targets

Wei Xiong1, Bingpeng Zhou2, Jian Shi3

  • 1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Cell and Developmental Biology
|December 5, 2025
PubMed

Insights

G protein-coupled receptors (GPCRs) are key in prostate cancer (PCa) progression and therapy resistance. Targeting these receptors offers new strategies for treating castration-resistant prostate cancer (CRPC).

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Prostate cancer (PCa) is a leading male malignancy, with castration-resistant prostate cancer (CRPC) presenting significant treatment challenges.
  • G protein-coupled receptors (GPCRs) are emerging as critical players in cancer progression, metastasis, and resistance to therapy.

Purpose of the Study:

  • To review the role of GPCRs, including orphan, chemokine, and hormone-sensitive receptors, in PCa.
  • To elucidate how GPCRs influence oncogenic processes in PCa.
  • To discuss novel therapeutic strategies targeting GPCRs for PCa treatment.

Main Methods:

  • Literature review focusing on GPCRs in prostate cancer.
  • Analysis of GPCR modulation of key oncogenic pathways (e.g., androgen receptor signaling).
  • Synthesis of research on therapeutic interventions targeting GPCRs.

Main Results:

  • GPCRs significantly regulate tumor progression, metastasis, and therapy resistance in PCa.
  • Specific GPCRs influence androgen receptor signaling, cell proliferation, migration, and immune evasion.
  • Targeting GPCRs, via biased ligands and combination therapies, shows therapeutic promise.

Conclusions:

  • GPCRs are crucial regulators of PCa pathogenesis and CRPC development.
  • Understanding GPCR mechanisms provides a foundation for developing novel PCa therapies.
  • Targeting GPCRs represents a promising avenue for future drug development in prostate cancer.
Keywords:
G protein-coupled receptorschemokine receptorshormone-responsive GPCRsorphan receptorsprostate cancer

More Related Videos

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

14.9K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K

Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
16.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
131.3K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
3.9K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.8K
GTPases and their Regulation02:14

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.7K