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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

447
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

431
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
431

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Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes
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Decoding Immune Influence: A Mendelian Randomisation Study on Dilated Cardiomyopathy.

Wei Gao1,2,3,4,5, Hui Wang1,2,3,4,5, Jian-Long Wang1,2,3,4,5

  • 1Heart Center, Tianjin Third Central Hospital Tianjin, China.

European Cardiology
|December 5, 2025
PubMed
Summary
This summary is machine-generated.

Elevated CD4+ regulatory T-cells (Tregs) causally increase the risk of dilated cardiomyopathy (DCM). This immune cell trait highlights the role of immune dysregulation in DCM development, impacting cardiovascular health.

Keywords:
Dilated cardiomyopathyMendelian randomisation analysiscausalitycellular immunitygenome-wide association studyregulatory T cells

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Area of Science:

  • Immunology
  • Cardiovascular Disease Genetics
  • Genetic Epidemiology

Background:

  • Dilated cardiomyopathy (DCM) is a major cause of heart failure, influenced by genetic and environmental factors.
  • The immune system's role in DCM pathogenesis is not fully understood.
  • Investigating immune cell traits offers potential insights into DCM development.

Purpose of the Study:

  • To investigate the causal relationship between immune cell traits and DCM risk using Mendelian randomization (MR).
  • To identify specific immune factors that may contribute to the development of DCM.

Main Methods:

  • A two-sample MR analysis was performed using genome-wide association study data for 731 immune cell traits and DCM.
  • Inverse-variance weighting was the primary analysis method, with MR-Egger and MR-PRESSO used for sensitivity analyses.
  • Genetic mapping and pathway enrichment analyses were conducted on identified immune traits.

Main Results:

  • An increased relative count of CD4+ regulatory T-cells (Tregs) was causally associated with a higher risk of DCM.
  • Each unit increase in genetically predicted CD4+ Tregs increased DCM odds by 14.4% (OR 1.144, p=9.36E-05).
  • Genetic mapping linked this immune trait to genes involved in inflammation and leukocyte adhesion in cardiovascular tissues.

Conclusions:

  • Elevated CD4+ Treg levels are implicated as a causal factor in DCM development.
  • Immune dysregulation, specifically involving Tregs, plays a critical role in DCM pathogenesis.
  • Further research is needed to confirm these findings and explore underlying biological mechanisms.