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Considerations for Spatial Omics, Metabolite Analyses, and Tissue-Harvesting Artifacts.
Jörg Hanrieder1,2,3, Ramon Sun4,5,6, Shane R Ellis7
1Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, Mölndal, Sweden.
Journal of Neurochemistry
|December 5, 2025
Summary
Emerging spatial biology techniques offer high molecular specificity for mapping neurochemical changes. Proper tissue preparation, including enzyme inactivation, is crucial to prevent artifacts and ensure accurate results in spatial omics analyses.
Area of Science:
- Spatial biology
- Neuroscience
- Analytical chemistry
Background:
- Novel analytical technologies are advancing the mapping of neurochemical changes in situ.
- Spatial mass spectrometry (MS imaging, MSI), spatial transcriptomics, and probe-based spatial omics offer superior molecular specificity and spatial precision over traditional methods.
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