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Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
Published on: May 29, 2017
Automated Synthesis of NET-Targeted PET Tracers [18F]4F-mHPG and [18F]3F-pHPG through Photocatalyzed
Yarong Cao1, Yang Xie1, Lili Pan1
1Department of Nuclear Medicine and Clinical Nuclear Medicine Research Lab, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
None:
The NET-targeted radiotracers [18F]4F-mHPG and [18F]3F-pHPG have demonstrated promising clinical applications; however, the preparation of these tracers remains challenging. Herein, we report an improved synthesis protocol that enables the efficient automated production of two PET tracers via photocatalyzed 18F-deoxyfluorination. [18F]4F-mHPG and [18F]3F-pHPG were prepared in excellent n.d.c. RCYs of 31.3 ± 0.4% and 22.4 ± 1% in only 1 h from readily available precursors, and further validated on the PC12 tumor model for head-to-head comparison.
