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Updated: Jan 9, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
Use of SGLT2 (Sodium-Glucose Cotransporter 2) Inhibitors in Pulmonary Hypertension
Benoit Aguado1, Grégoire Ruffenach1, Thomas Lacoste-Palasset1
1Université Paris-Saclay, French National Institute for Health and Medical Research, UMR_S 999, Hypertension Pulmonaire: Physiopathologie and Innovation Thérapeutique, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Hôpital Marie Lannelongue (Groupe Hospitalier Paris Saint Joseph), European Reference Network on Rare Respiratory Diseases, Fédération Hospitalo-Universitaire André Cournand, Le Plessis Robinson, France (B.A., G.R., T.L.-P., M.G., F.B., M.H., D.M., F.A.).
Abstract:
Inhibiting SGLT2 (sodium-glucose cotransporter 2) has recently transformed the medical care of patients with left heart disease. Right ventricular failure is a major predictor for patients suffering from pulmonary hypertension of various causes, including those with postcapillary pulmonary hypertension due to left heart disease. Similar to how SGLT2 inhibition benefits patients with left heart failure, recent studies have suggested utilizing these molecules to enhance right ventricular function in pulmonary hypertension. In this review, we summarize the current knowledge on the use of SGLT2is (SGLT2 inhibitors) in pulmonary hypertension. Further dedicated trials are necessary to establish their role in right ventricular pulmonary vascular disease.
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