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Updated: Jan 9, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Bicyclo[1.1.0]butanes
Tianmeng Jia1,2, Lili Chen1, Wei Sun1
1State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Abstract:
Bicyclo[1.1.0]butanes (BCBs) have attracted considerable interest in organic synthesis due to their versatile reactivity. However, the asymmetric synthesis of these strained systems remains a formidable challenge. We herein report an iridium-catalyzed enantioselective C(sp3)-H borylation of BCBs, providing access to a range of optically active borylated BCBs with high enantioselectivities. We also demonstrated synthetic applications by downstream transformations, particularly in the stereoselective preparation of optically active multisubstituted cyclobutenes.
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