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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

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Published on: February 13, 2016

Mechanically robust PVA/SA semi-IPN hydrogels for highly effective temperature-triggered linagliptin delivery.

Yue Wang^1,2, Guineng Li², Yeying Li²

¹School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang, 330013, China. 1020100997@jxstnu.edu.cn.

Physical Chemistry Chemical Physics : PCCP

|December 5, 2025

Summary

This study developed a flexible, robust hydrogel for diabetic wound healing. The material effectively delivers Linagliptin (LIN) in a temperature-controlled manner, enhancing therapeutic potential.

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Polymer Chemistry
Wound Healing Technologies

Background:

Hydrogels are promising for wound healing due to their mechanical properties and drug-delivery capacity.
Achieving optimal mechanical strength and drug delivery simultaneously in hydrogels remains a significant challenge.

Purpose of the Study:

To develop a novel semi-interpenetrating polymer network (semi-IPN) hydrogel for diabetic wound healing.
To optimize the hydrogel for enhanced mechanical properties, high drug loading, and temperature-responsive drug release.

Main Methods:

Fabrication of a poly(vinyl alcohol) (PVA) and sodium alginate (SA) semi-IPN hydrogel using freeze-thaw cycling.
Component optimization to achieve desired material characteristics.
Loading of Linagliptin (LIN), a DPP-4 inhibitor, and evaluation of release kinetics.

Main Results:

The optimized hydrogel exhibited excellent softness (Young's modulus: 32.5 kPa), high stretchability (fracture strain: 283.9%), and high water content (96.46%).
Achieved high Linagliptin loading efficiency (89.25%) and cumulative release (85.17%) at physiological temperature.
Demonstrated temperature-responsive release, with minimal release at low temperatures and sustained release at physiological temperatures.

Conclusions:

The developed PVA/SA semi-IPN hydrogel offers a promising platform for diabetic wound healing.
The material integrates mechanical robustness, temperature-triggered drug delivery, and efficient Linagliptin loading/release.
This novel therapeutic material shows significant potential for advanced wound care applications.