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Genomes of enteric pathogen isolates from polymicrobial infections in cases of pediatric diarrhea

Bernadette A Hritzo1,2,3, Jane M Michalski Wilhelm1,2,3, David A Rasko1,2,3,4

  • 1Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Microbiology Resource Announcements
|December 5, 2025
PubMed

Insights

Most human enteric infections involve multiple pathogens, not just one. This study details the genomes of Escherichia coli, Shigella, and Aeromonas species found together in polymicrobial infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Enteric infections frequently involve multiple microbial species.
  • Understanding polymicrobial infections is crucial for effective treatment.

Purpose of the Study:

  • To characterize the genomes of bacterial isolates from polymicrobial enteric infections.
  • To investigate the genetic makeup of Escherichia coli, Shigella, and Aeromonas in co-infections.

Main Methods:

  • Whole-genome sequencing of bacterial isolates.
  • Analysis of genomic data from polymicrobial samples.

Main Results:

  • Genomic data were obtained for Escherichia coli, Shigella spp., and Aeromonas spp. from four study subjects.
  • The study focused on isolates from polymicrobial enteric infections.

Conclusions:

  • This research provides genomic insights into common enteric pathogens involved in polymicrobial infections.
  • Further research can build upon these genomic descriptions to understand pathogen interactions.
Keywords:
entericgenomepolymicrobial

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