Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cohesion

Cohesion

Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...

Dehydration Synthesis

Dehydration Synthesis

Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.Synthesis of carbohydratesSugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from one reactant...

Membrane Fluidity

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...

Membrane Fluidity

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...

Drying Shrinkage

Drying Shrinkage

When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...

Flashbulb Memory

Flashbulb Memory

A flashbulb memory is a highly vivid and detailed memory, often linked to events of significant emotional impact. These memories stand out in contrast to everyday memories due to their clarity and the precision with which they are recalled. The strong emotions associated with the event act as a catalyst, ensuring that specific details, such as one's location, actions, and even peripheral elements, are etched into memory with remarkable accuracy. For example, many people can vividly recall where...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

C-terminally engineered nucleopeptide-based soft materials exhibiting antibacterial and antifungal efficacy against multi-drug-resistant strains.

Organic & biomolecular chemistry·2026

Same author

Entropy, Free Energy, and a Generalized Order Parameter for Liquid Crystal Phases of Chiral and Achiral Rods.

Journal of chemical theory and computation·2026

Same author

Memory control of ice growth during non-equilibrium freezing of water.

The Journal of chemical physics·2026

Same author

Lysine containing amphiphilic peptide-based non-cytotoxic soft materials with potential antifungal and antibacterial activities for 3D cell culture.

Soft matter·2026

Same author

Ligand-induced release of HNO/NO<sup>-</sup> from a cobalt(II)-nitrosyl complex.

Chemical communications (Cambridge, England)·2026

Same author

Mechanistic insights into crossover-dependent nuclease resistance of PX <i>vs.</i> dsDNA using enhanced sampling.

Nanoscale·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Dynamic self-shrinking peptide hydrogels with shape memory and self-healing properties.

Biplab Mondal¹, Sandip Mandal², Tanushree Mondal¹

¹School of Biological Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, India. bcab@iacs.res.in.

|December 5, 2025

Summary

This summary is machine-generated.

Three novel peptide amphiphiles form self-shrinking and self-healing hydrogels. Their unique properties and nanoscale structures are sequence-dependent, confirmed by molecular dynamics simulations.

More Related Videos

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

Related Experiment Videos

Last Updated: Jun 12, 2026

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

Area of Science:

Supramolecular Chemistry
Materials Science
Biomaterials Engineering

Background:

Peptide amphiphiles are versatile building blocks for self-assembled nanomaterials.
Hydrogels with tunable properties are crucial for advanced applications.
Understanding sequence-structure-property relationships is key for rational design.

Purpose of the Study:

To synthesize and characterize novel peptide amphiphiles.
To investigate their hydrogel formation, self-shrinking, self-healing, and shape-memory properties.
To elucidate the influence of amino acid sequence on self-assembly and hydrogel architecture.

Main Methods:

Synthesis and purification of three aromatic amino acid-based peptide amphiphiles.
Characterization of hydrogel properties at physiological pH (7.46).
Coarse-grained molecular dynamics simulations to study sequence-dependent self-assembly.

Main Results:

Successful synthesis and characterization of peptide amphiphiles.
Formation of hydrogels exhibiting time-dependent self-shrinking behavior.
Demonstrated self-healing abilities and 3D shape-memory properties.
Sequence variation significantly impacted self-shrinking extent and hydrogel architecture.
Molecular dynamics simulations corroborated experimental findings on sequence-driven assembly.

Conclusions:

Peptide amphiphile sequence dictates hydrogel properties, including self-shrinking and self-healing.
Coarse-grained molecular dynamics simulations effectively predict self-assembly behavior.
These findings offer insights for designing advanced peptide-based biomaterials.