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Updated: Jan 9, 2026

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
Cu-Fe3O4 Nanozyme Reverses Age-Impaired Alveolar Healing via Reactive Oxygen-Nitrogen Species Scavenging and
Zheng Cheng1, Jikang Cao1, Haobo Lin1
1Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Jiangsu Province Engineering Research Centre of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Abstract:
Age-related decline in bone healing capacity poses significant challenges for tooth extraction recovery in the elderly. Elevated reactive oxygen-nitrogen species (RONS) and impaired mitophagy drive this pathology. We engineered bimetallic Cu-Fe3O4 nanoclusters with oxygen vacancies (OVs) via hydrothermal synthesis. The abundant oxygen vacancies and bimetallic synergy endow Cu-Fe3O4 with exceptional enzyme-mimicking activity, enabling efficient scavenging of excess RONS and activation of mitophagy in senescent cells in vitro, thereby reversing functional decline. Owing to its excellent biocompatibility and negligible in vivo toxicity, Cu-Fe3O4 accelerates tooth extraction wound healing in aged animal models.
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