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Updated: Jan 9, 2026

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Spirocyclopentane as a Novel Scaffold for Potent Ghrelin Receptor Full Agonists

Cristina Gardelli1, Antonio Llinas2, Igor Shamovsky3

  • 1Projects Department, Respiratory and Immunology, R&D BioPharmaceuticals, AstraZeneca, Mölndal SE-43183, Sweden.

Journal of Medicinal Chemistry
|December 5, 2025
PubMed
Summary

Researchers developed a novel compound (22) to combat muscle wasting and cachexia. This ghrelin receptor agonist shows promise for treating chronic diseases by increasing insulin-like growth factor-1.

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