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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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The untransfusable patient.

Kathryn E Webert1,2, Michelle P Zeller1,3,4

  • 1Canadian Blood Services, Hamilton, Ontario, Canada.

Hematology. American Society of Hematology. Education Program
|December 5, 2025
PubMed
Summary
This summary is machine-generated.

Managing anemia without red cell transfusions requires a multidisciplinary approach. This involves pre-operative screening, anemia correction, and intraoperative strategies to minimize blood loss for patient safety.

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Area of Science:

  • Transfusion Medicine
  • Anesthesiology
  • Surgical Management

Background:

  • Red cell transfusions are standard for anemia, but some patients cannot or refuse them.
  • Transfusions carry risks, necessitating careful benefit-risk assessment for all patients.

Purpose of the Study:

  • To outline strategies for managing patients unable or unwilling to receive blood transfusions.
  • To emphasize a multidisciplinary approach for optimizing care in various clinical settings, including surgery.

Main Methods:

  • Screening patients for anemia at least 6 weeks before planned surgery or delivery.
  • Correcting anemia and documenting bleeding history.
  • Developing multidisciplinary plans for pre-, intra-, and postoperative periods, including emergency management.

Main Results:

  • Implementation of strategies to minimize blood loss during surgery.
  • Postoperative management focused on reducing blood sampling and optimizing anemia tolerance.
  • Documentation of patient decisions regarding blood products and acceptable interventions.

Conclusions:

  • Safe and effective management is possible for patients refusing or unable to receive transfusions.
  • Clear communication, documentation, and multidisciplinary team involvement are crucial for successful patient care.