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Updated: Jan 6, 2026
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Synthesis of Visible-Light-Mediated Cyclopropanes and Cyclic Sultines by Deacylative Radical Addition-Polar
Hao Wu1,2, Shuguang Chen1, Hui Wang1
1Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials (State Key Laboratory Cultivation Base), College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, P. R. China.
Abstract:
Synthesis of cyclopropanes and five-membered sultines using a two-component and three-component radical addition-polar cyclization cascade (RPCC) strategy has been reported here, respectively. The cyclopropanation method features a broad substrate scope (47 examples), excellent functional group tolerance, and a gram-scale reaction, highlighting its synthetic utility. Furthermore, the successful application of dihydroquinozolinones derived from di- and trifluoroacetophenone to prepare cyclic sultines expanded the versatility of these perfluoromethylation reagents.
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