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Diastolic Dysfunction in Type 2 Diabetes and Its Correlation with Nephropathy and Associated Risk Factors.

Kashish1, Tushar Singh, Ashok Kumar

  • 1Department of General Medicine, Santosh Medical College, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India.

Annals of African Medicine
|December 5, 2025
PubMed
Summary
This summary is machine-generated.

Diabetic nephropathy is common in type 2 diabetes and linked to left ventricular diastolic dysfunction. Early detection and management of kidney disease and diabetes are crucial for heart health.

Keywords:
Diabetic nephropathyNéphropathie diabétiquediabète de type 2diastolic dysfunctiondysfonction diastoliquedysfonction diastolique ventriculaire gauchefacteurs de risqueleft ventricular diastolic dysfunctionrisk factorstype 2 diabetes

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Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Limited understanding of diabetes impact on left ventricle diastolic function in chronic renal failure.
  • Type 2 diabetes mellitus (T2DM) and diabetic nephropathy are significant health concerns.
  • Diastolic dysfunction is an early indicator of cardiac changes.

Purpose of the Study:

  • To explore the link between diabetic nephropathy and diastolic dysfunction in T2DM patients.
  • To assess the prevalence of diastolic dysfunction in T2DM with varying degrees of nephropathy.
  • To identify factors associated with diastolic dysfunction in this population.

Main Methods:

  • Cross-sectional study of 101 T2DM patients (age >35-<70 years).
  • Diabetic nephropathy assessed via urine albumin and serum creatinine.
  • Diastolic function evaluated using echocardiography and tissue Doppler imaging (E/E' ratio).

Main Results:

  • 57.4% of T2DM patients had diastolic dysfunction (Grade I: 34.7%, Grade II: 18.8%, Grade III: 4.0%).
  • Higher prevalence in males (64.3%) vs. females (48.9%).
  • Direct relationship found between worsening diabetic nephropathy (declining eGFR) and diastolic dysfunction.

Conclusions:

  • High prevalence of left ventricular diastolic dysfunction (LVDD) in T2DM, associated with age, glycemic control, and diabetic nephropathy.
  • Glycemic control and diabetes duration may be key determinants of LVDD.
  • Emphasizes the need for early detection and aggressive management of LVDD in T2DM patients with nephropathy.