Related Experiment Video
Updated: Jan 9, 2026

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
Published on: May 24, 2024
The Role of Migrasomes in Health and Disease
Dong Jiang1, Li Yu2
1State Key Laboratory of Transvascular Implantation Devices, Department of Cardiology, Transvascular Implantation Devices Research Institute, The Second Affiliated Hospital and School of Basic Medical Sciences, Zhejiang University, Hangzhou, China.
Abstract:
Migrasomes are specialized organelles that form during cell migration and play a critical role in intercellular communication and disease progression. First discovered in 2012 and reported in 2015, these organelles are characterized by their unique biogenesis on retraction fibers and their role in spatiotemporal signaling, distribution of bioactive molecules, and maintenance of cellular homeostasis. This review provides a comprehensive overview of migrasome biology, exploring their discovery, mechanisms of formation, physiological functions, and pathological implications. We examine their dual roles in both health and disease, highlighting their potential as diagnostic biomarkers and therapeutic targets. Additionally, we discuss the challenges and future directions in migrasome research, emphasizing the importance of foundational discoveries and advanced methodologies to fully realize their clinical potential.
Related Concept Videos
Role of Myosin in Cell Migration
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Cell Migration
Cell Migration
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Mismatch Repair
Cytoskeletal Coordination in Cell Migration

