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Updated: Jan 9, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Posttranslational modifications in regulating Notch signaling pathway and tumor angiogenesis: from molecular

Jiaan Wang1, Meng Zhang1, Donglai Wang1

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases & Department of Medical Genetics, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

Journal of Molecular Cell Biology
|December 5, 2025
PubMed

Insights

Targeting Notch signaling pathway posttranslational modifications (PTMs) offers a novel strategy to control tumor angiogenesis. Understanding these PTMs is crucial for developing effective cancer therapies with reduced toxicity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Tumorigenesis involves intricate interactions with the vascular system, making angiogenesis a key therapeutic target.
  • The Notch signaling pathway regulates tumor angiogenesis but faces clinical translation challenges due to toxicity.
  • Posttranslational modifications (PTMs) critically influence Notch signaling integrity and function.

Purpose of the Study:

  • To explore the crosstalk between Notch signaling and tumor angiogenesis.
  • To investigate the regulatory roles of PTMs on Notch molecules in tumor angiogenesis.
  • To evaluate the therapeutic potential of targeting Notch-related PTMs for anti-angiogenic cancer strategies.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of molecular mechanisms linking PTMs, Notch signaling, and angiogenesis.
  • Discussion of therapeutic challenges and clinical translation barriers.

Main Results:

  • Notch signaling is a central regulator of tumor angiogenesis.
  • Specific PTMs like glycosylation and ubiquitination are vital for Notch pathway integrity.
  • Dysfunctional Notch-related PTMs contribute to pathological angiogenesis.

Conclusions:

  • Targeting Notch-related PTMs presents a promising avenue for anti-angiogenic cancer therapy.
  • Elucidating the PTMs-Notch-angiogenesis nexus is key for tumor progression understanding.
  • Overcoming clinical translation barriers for PTM-targeted therapies is essential for oncology.
Keywords:
Notch signalingangiogenesisposttranslational modificationstumor

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