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Updated: Jan 9, 2026
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Prevention of immunoglobulin on ventilator-associated pneumonia in critically ill children:a retrospective study
Xinyu Zou1, Meizhu Xue2, Xuguo Wang3
1Pediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, 215000, Jiangsu, China.
Background:
Ventilator-associated pneumonia (VAP), a leading ICU-acquired infection, prolongs ICU stays, increases costs, and elevates mortality. The impact of intravenous immunoglobulin (IVIG) on VAP incidence in children remains unclear.
Methods:
We enrolled 228 PICU patients undergoing mechanical ventilation (≥48 h) from June 2019 to June 2023. Seventy-five of them developed VAP (VAP group), while the remaining 153 children constituted the non-VAP group. We analyzed the relationship between IVIG administration within 30 days prior to ventilation and the occurrence of VAP.
Results:
The incidence of ventilator-associated pneumonia (VAP) was 32.9 % in the cohort. Mortality was significantly higher among patients with VAP (40.00 % vs. 26.10 %, p = 0.033). In unadjusted analyses, the administration of IVIG within 30 days before intubation was associated with a lower incidence of VAP (27.54 % vs. 41.11 %, p = 0.033) and a reduced rate of Acinetobacter baumannii infection (2.9 % vs. 15.6 %, p = 0.001). After adjusting for potential confounders, IVIG administration remained independently associated with a substantially reduced risk of VAP (aOR = 0.448, 95 % CI: 0.288-0.697, p < 0.001). Conversely, tracheotomy, underlying conditions, and malnutrition were among the factors associated with an increased risk.
Conclusions:
IVIG administration within one month prior to ventilation may be associated with a reduced incidence of VAP.
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