Related Experiment Video

Updated: Jan 9, 2026

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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Pyroptosis as a molecular bridge: linking gasdermin activation to enhanced anti-tumor immunity in immunotherapy

Di Wu1, Yinghua Zhang2, Yifei Guo3

  • 1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.

Biochemical Pharmacology
|December 5, 2025
PubMed

Insights

Pyroptosis, a form of programmed cell death, shows promise for cancer immunotherapy by potentially overcoming challenges like drug resistance and poor T cell response. This review explores its mechanisms and therapeutic applications.

Area of Science:

  • Immunology
  • Cell Biology
  • Oncology

Background:

  • Pyroptosis is a programmed inflammatory cell death pathway regulated by gasdermins.
  • Tumor immunotherapy aims to harness the immune system against cancer but faces challenges like immune evasion and drug resistance.

Purpose of the Study:

  • To review the molecular mechanisms of pyroptosis.
  • To explore the relationship between pyroptosis and tumor immunity.
  • To discuss pyroptosis induction as a strategy for cancer immunotherapy.

Main Methods:

  • Literature review of pyroptosis and cancer immunotherapy.
  • Analysis of molecular pathways involved in pyroptosis.
  • Examination of studies linking pyroptosis to anti-tumor immune responses.

Main Results:

  • Pyroptosis can trigger robust anti-tumor immune responses.
  • Inducing pyroptosis may overcome common immunotherapy resistance mechanisms.
  • Gasdermin-mediated pyroptosis is a key pathway for eliciting immune activation.

Conclusions:

  • Pyroptosis represents a promising therapeutic strategy for enhancing cancer immunotherapy.
  • Further research into pyroptosis induction pathways can optimize its clinical application.
  • Targeting pyroptosis could offer a novel approach to combatting cancer drug resistance.
Keywords:
Cell deathImmunotherapiesPyroptosisTumor

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