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Reference Intervals of Lateral Ventricles for Extremely Pre-Term Infants: Multicenter Cohort Research
Junyi Yan1, Yang Gao2, Liangyu Guo3
1NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, China; Department of Clinical Laboratory, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, China.
This study establishes reference values and intervention cutoffs for lateral ventricle measurements in extremely premature infants. These findings aid in managing post-hemorrhagic ventricular dilation in this vulnerable population.
Area of Science:
- Neonatal Neurology
- Pediatric Neuroimaging
Background:
- Accurate assessment of lateral ventricle size is crucial for managing extremely premature infants.
- Establishing reliable reference intervals and intervention cutoffs is essential for clinical decision-making.
Purpose of the Study:
- To establish reference intervals and intervention cutoffs for anterior horn width (AHW), ventricular index (VI), and thalamo-occipital distance (TOD) in extremely premature infants.
- To provide a comprehensive comparison of available reference values for these measurements.
Main Methods:
- Prospective study of 353 neurologically healthy extremely premature infants.
- Measurement of AHW, VI, and TOD at enrollment (U1) and 4 weeks later (U2).
- Analysis using multiple linear regressions and mixed linear models to determine correlations and time-varying trends.
Main Results:
- AHW, VI, and TOD were positively correlated with birth weight (p<0.05).
- These indices showed a significant increase over time (p<0.001).
- The 97th percentile and 4 mm above it were identified as key thresholds.
Conclusions:
- The study provides essential reference values and intervention cutoffs for lateral ventricle measurements in extremely premature infants.
- These data support clinical management and monitoring of post-hemorrhagic ventricular dilation.
- Offers an extensive comparison of existing reference values for these neuroimaging parameters.
