A new polyketide from Penicillium sp. HK-G2 and its inhibitory activity against α-glucosidase
Jie Zhen Shi1, Yan-Li Zhang2, Jin Hua Yu1
1Yunnan University of Chinese Medicine, Kunming, P. R. China.
Abstract:
A new polyketide derivative, pennafuredin (1), along with one known compound nafuredin (2), were isolated from Penicillium sp. HK-G2. The planar structure of pennafuredin (1) was characterised by comprehensive NMR spectroscopic analyses and HR-ESI-MS data. Its absolute configuration was elucidated by ML_J_DP4 probability analysis and ECD calculation. Pennafuredin (1) exhibited potent α-glucosidase inhibitory activity, with an inhibition rate of 83.97 ± 3.17% at a concentration of 1 mg/mL. Molecular docking analysis revealed that pennafuredin (1) displayed a superior binding affinity to α-glucosidase (-7.29 kcal/mol).
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