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Knowledge distillation-based lightweight MobileNet model for diabetic retinopathy classification.
Fitsum Mesfin Dejene1, Yehualashet Megersa Ayano2, Degaga Wolde Feyisa3
1Ethiopian Artificial Intelligence Institute, Addis Ababa, Ethiopia. fitsummesfin12@gmail.com.
Scientific Reports
|December 5, 2025
Summary
A new lightweight deep learning model effectively screens for diabetic retinopathy (DR) using retinal images. This approach offers a viable, efficient solution for early DR detection, especially in underserved regions.
Area of Science:
- Ophthalmology
- Artificial Intelligence
- Medical Imaging
Background:
- Diabetic retinopathy (DR) is a leading cause of preventable blindness globally.
- Manual screening of retinal images is labor-intensive and faces resource limitations, particularly in low-income countries.
- Deep learning (DL) shows promise for DR detection but often requires substantial computational resources.
Purpose of the Study:
- To develop a lightweight deep learning model for efficient diabetic retinopathy screening.
- To address the limitations of large DL models on resource-constrained devices.
- To enable effective DR detection suitable for edge deployment.
Main Methods:
- Proposed a lightweight student model based on the MobileNet architecture.
- Utilized depthwise separable convolutions for efficient model design.
- Employed knowledge distillation to transfer performance from a larger model to the lightweight one.
Main Results:
- Achieved 98.38% accuracy, precision, and recall for binary classification on the APTOS 2019 dataset.
- Attained 93.03% accuracy for ternary classification on the APTOS 2019 dataset.
- The model's efficient design is suitable for deployment on edge devices.
Conclusions:
- The proposed lightweight DL model provides an efficient and accurate method for diabetic retinopathy screening.
- Knowledge distillation effectively creates compact models for medical image analysis.
- This technology can help bridge the gap in DR screening accessibility, especially in resource-limited settings.
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